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Gene family evolution underlies cell-type diversification in the hypothalamus of teleosts
Hundreds of cell types form the vertebrate brain but it is largely unknown how similar cellular repertoires are between or within …
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Regulation of stem/progenitor cell maintenance by BMP5 in prostate homeostasis and cancer initiation
Tissue homeostasis relies on the fine regulation between stem and progenitor cell maintenance and lineage commitment. In the adult …
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Lamina-Dependent Stretching and Unconventional Chromosome Compartments in Early C. elegans Embryos
Current models suggest that chromosome domains segregate into either an active (A) or inactive (B) compartment. B-compartment chromatin …
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Cross-Species Analysis of Single-Cell Transcriptomic Data
The ability to profile hundreds of thousands to millions of single cells using scRNA-sequencing has revolutionised the fields of cell …
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Modulation of apoptotic response by LAR family phosphatases–cIAP1 signaling during urinary tract morphogenesis
The elimination of unwanted cells by apoptosis is necessary for tissue morphogenesis. However, the cellular control of morphogenetic …
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Bmp signaling maintains a mesoderm progenitor cell state in the mouse tailbud
Caudal somites are generated from a pool of progenitor cells located in the tailbud region. These progenitor cells form the presomitic …
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Lineage Specification from Prostate Progenitor Cells Requires Gata3-Dependent Mitotic Spindle Orientation
During prostate development, basal and luminal cell lineages are generated through symmetric and asymmetric divisions of bipotent basal …
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A Point Mutation in p190A RhoGAP Affects Ciliogenesis and Leads to Glomerulocystic Kidney Defects
Rho family GTPases act as molecular switches regulating actin cytoskeleton dynamics. Attenuation of their signaling capacity is …
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Expression analysis of the peroxiredoxin gene family during early development in Xenopus laevis
Development in the frog, Xenopus laevis, requires the utilization of yolk glyco-lipo-proteins in a temporally- and spatially-dependent …
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